मराठी

Errors in DNA Replication and Its Repair

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Estimated time: 2 minutes
CISCE: Class 12

Key Points: Errors in DNA Replication and Its Repair

  • While the initial DNA replication error rate is roughly 3 in 100,000 base pairs, proofreading reduces the final error rate to 1 in 1 billion.
  • Repair enzymes within the DNA polymerase complex immediately proofread each new base pair as it forms to remove and replace mistakes.
  • Defective DNA segments are cut out by nucleases, and the correct replacement segments are joined together by the enzyme ligase.
  • Specialised enzymes continuously monitor and repair DNA damage that occurs between replication cycles.
  • Environmental damage, such as pyrimidine dimers caused by ultraviolet light, is corrected through a process called excision repair.
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