मराठी

Regulation of Gene Expression

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Estimated time: 3 minutes
Maharashtra State Board: Class 12

Key Points: Regulation of Gene Expression

  • Gene regulation = switching genes ON or OFF based on the cell's requirement and stage of development.
  • In eukaryotes, regulation occurs at 4 levels: Transcriptional (primary transcript), Processing (splicing), Transport (mRNA from nucleus to cytoplasm), and Translational.
  • In prokaryotes, control of transcriptional initiation rate is the main site for gene expression control.
  • E. coli produces β-galactosidase to break lactose → galactose + glucose. If lactose is absent, the enzyme is not produced, proving the environment regulates gene expression.
  • Enzymes synthesized based on substrate availability are called inducible enzymes. The process = induction; the triggering molecule = inducer. This is a positive control.
  • Feedback repression = when the end product (e.g., amino acid) is already available, genes for its production are switched OFF. This is a negative control.
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