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Karnataka Board PUCPUC Science 2nd PUC Class 12

Diseases Caused by Protozoa > Amoebiasis (Amoeboic dysentery)

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Estimated time: 15 minutes
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Introduction

Amoebiasis, also called amoebic dysentery, is a protozoan disease caused by Entamoeba histolytica. The parasite mainly infects the large intestine.

Entamoeba histolytica

Maharashtra State Board: Class 12

Life Cycle

Entamoeba histolytica Life Cycle Stages:

Phase Developmental Stages Key Features & Events
Active Feeding Trophozoite Active, motile form containing ingested R.B.C.s and food vacuoles; multiplies via binary fission.
Encystment Precystic form → Cyst → Binucleate cyst → Quadrinucleate cyst Trophozoite rounds up, develops a cyst wall, chromatoid bodies, and glycogen vacuoles, and matures into the four-nucleated stage.
Excystment Quadrinucleate cyst → Excystment → Metacystic Amoeba The cyst wall ruptures, releasing the metacystic amoeba into the host.
Multiplication Metacystic Amoeba → Amoebulae Undergoes asexual reproduction (division) to produce multiple amoebulae, which subsequently mature into trophozoites.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Transmission

  • It spreads through contaminated food and water.
  • Infection occurs by the faeco-oral route.
  • Houseflies act as mechanical carriers and help in transmission.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Symptoms

  • Common symptoms include diarrhoea, abdominal pain, abdominal cramps, and constipation.
  • Blood and mucus may be present in the stool.
  • Flatulence may also occur.
  • In more severe cases, the liver may be affected, leading to hepatomegaly or a liver abscess.
  • Fever and weight loss may be seen in such cases.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Diagnosis and Treatment

Diagnosis:

  • Diagnosis is made by microscopic examination of the stool.

Treatment:

  • It is treated with antiamoebic drugs.
  • Commonly used drugs include metronidazole and tinidazole.
  • In severe liver involvement, aspiration may be required.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Prevention

  • Maintain personal hygiene.
  • Drink safe water such as boiled, filtered, or chlorinated water.
  • Eat clean and properly covered food.
  • Ensure proper sanitation and sewage disposal.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Key Points: Amoebiasis (Amoebic dysentery)

Aspect Details
Disease & Type Amoebiasis (Amoebic Dysentery) - protozoan disease of the large intestine
Causative organism Entamoeba histolytica
Mode of spread Contaminated food and water; faeco-oral route; houseflies as mechanical carriers
Symptoms Diarrhoea, abdominal pain, cramps, constipation, blood and mucus in stool, flatulence
Severe effects Liver involvement - hepatomegaly or liver abscess, fever, weight loss
Diagnosis Microscopic examination of stool
Treatment Antiamoebic drugs - metronidazole, tinidazole; aspiration in severe liver cases
Prevention Personal hygiene, safe (boiled/filtered/chlorinated) water, clean covered food, proper sanitation and sewage disposal
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