The process of protein synthesis in which the message on mRNA is decoded with the help of tRNA to form a specific sequence of amino acids is called translation.
Topics
Reproduction in Lower and Higher Plants
- Reproduction
- Asexual Reproduction
- Asexual Reproduction in Unicellular Organisms > Binary Fission
- Binary Fission > Simple Binary Fission
- Binary Fission > Transverse Binary Fission
- Binary Fission > Longitudinal Binary Fission
- Asexual Reproduction in Unicellular Organisms > Multiple Fission
- Asexual Reproduction in Unicellular Organisms > Budding
- Asexual Reproduction in Multicellular Organisms > Fragmentation
- Asexual Reproduction in Multicellular Organisms > Spore Formation
- Vegetative Reproduction or Vegetative Propagation
- Natural Vegetative Propagation
- Artificial Vegetative Propagation
- Sexual Reproduction
- Flower
- Structure and Development of Anther
- Microsporogenesis
- Structure and Development of Male Gametophyte
- Structure and Development of Ovule
- Types of Ovules (Based on Orientation)
- Types of Ovules (Based on Integuments)
- Megasporogenesis
- Development of Female Gametophyte or Embryo Sac
- Pollination
- Autogamy
- Cross-pollination
- Geitonogamy
- Agents and Types of Cross-pollination
- Anemophily
- Hydrophily
- Entomophily
- Ornithophily
- Cheiropteriphily
- Malacophily
- Outbreeding Devices
- Fertilization
- Pollen Pistil Interaction
- Artificial Hybridization or Artificial Fertilization
- Double Fertilization and Triple Fusion
- Endosperm
- Embryo
- Seed and Fruit Development
- Dormancy
- Apomixis
- Parthenocarpy
- Polyembryony
- Overview of Reproduction in Lower and Higher Plants
Reproduction in Lower and Higher Animals
- Reproduction
- Asexual Reproduction
- Asexual Reproduction in Animals > Gemmule Formation
- Asexual Reproduction in Multicellular Organisms > Budding
- Asexual Reproduction in Multicellular Organisms > Regeneration
- Sexual Reproduction
- Human Reproduction
- The Male Reproductive System
- Basic Concept of Testes
- Duct system of Male Reproductive Tract
- Accessory Glands of Male Reproductive System
- Semen (Seminal fluid)
- External Genitalia: Penis
- The Female Reproductive System
- Ovaries
- Female Reproductive Duct System
- External Genitalia: Vulva
- Mammary Glands
- Puberty
- Menstrual Cycle (Ovarian Cycle)
- Major Events of Menstrual Cycle
- Menstrual Hygiene
- Gametogenesis
- Spermatogenesis
- Structure of Sperm
- Oogenesis
- Structure of Secondary Oocyte
- Fertilisation in Human
- Embryonic Development in Human
- Fate of Germ Layers in Embryonic Development
- Stem Cells
- Pregnancy in Humans
- Placenta (Growth) in Human
- Parturition (Birth) in Human
- Lactation in Human
- Concept of Reproductive Health
- Birth Control
- Natural Contraceptive Methods
- Artificial Contraceptive Methods
- Amniocentesis
- Sexually Transmitted Diseases (STD) or Sexually Transmitted Infections (STI)
- Infertility
- Assisted Reproductive Technology (ART)
- Overview of Reproduction in Lower and Higher Animals
Inheritance and Variation
- Heredity
- Gregor Johann Mendel – Father of Genetics
- Mendel's Experiments on Inheritance
- Reasons for Mendel's Success
- Genetic Terminology
- Monohybrid Cross
- Dihybrid Cross
- Mendel's Laws > The Law of Dominance
- Mendel's Laws > The Law of Segregation (Law of Purity of Gametes)
- Mendel's Laws > The Law of Independent Assortment
- Back Cross and Test Cross
- Deviations from Mendel’s Findings
- Exceptions to Mendel's Principles > Incomplete Dominance
- Exceptions to Mendel's Principles > Co-Dominance
- Exceptions to Mendel's Principles > Multiple alleles
- Exceptions to Mendel's Principles > Pleiotropy
- Chromosomal Theory of Inheritance
- Chromosomes - The Carriers of Heredity
- Types of Chromosomes
- Linkage and Crossing Over
- Autosomal Inheritance
- Sex Linked Inheritance
- Colour blindness
- Haemophilia
- Sex Determination
- Sex Determination in Humans
- Sex Determination in Birds
- Sex Determination in Honey Bees
- Human Genetic Disorders
- Thalassemia
- Down's syndrome (Mongolian Idiocy)
- Turner's Syndrome
- Klinefelter's Syndrome
- Overview of Inheritance and Variation
Molecular Basis of Inheritance
- Deoxyribonucleic Acid (DNA)
- Griffith’s Experiment
- Avery, McCarty and MacLeod’s Experiment
- The Hershey-Chase Experiment
- Packaging of DNA Helix
- DNA Replication
- Meselson and Stahl’s Experiment
- Mechanism of DNA Replication
- Semi-Conservative Replication
- Protein Synthesis
- Transcription
- Transcription Unit and the Gene
- Genetic Code
- Characteristics of the Genetic Code
- Mutations and Genetic Code
- tRNA – the Adapter Molecule
- Translation
- Mechanism of Translation
- Regulation of Gene Expression
- Operon Concept
- The Lac Operon
- Genomics
- Human Genome Project
- DNA Fingerprinting
- Overview of Molecular Basis of Inheritance
Origin and Evolution of Life
- Origin of Life on Earth
- Redi's and Louis Pasteur’s Experiment
- Chemical Evolution of Life
- Urey and Miller’s Experiment
- The RNA World
- Organic Evolution
- Darwin’s Theory of Natural Selection (Darwinism)
- Basic Postulates of Darwinism
- Drawbacks and Criticism of Darwinism
- Mutation Theory
- Modern Synthetic Theory of Evolution
- Modern Synthetic Theory of Evolution > Genetic Variations
- Modern Synthetic Theory of Evolution > Natural Selection
- Modern Synthetic Theory of Evolution > Isolation
- Mechanism of Organic Evolution
- Hardy Weinberg’s Principle
- Adaptive Radiation
- Evidences of Organic Evolution
- Evidences of organic evolution > Palaeontology
- Connecting Links
- Homology and Homologous Organs
- Analogy and Analogous Organs
- Vestigial Organs
- Molecular (Genetic) Evidences
- Speciation
- Geological Time Scale
- Human Evolution
- Stages of Human Evolution
- Overview of Origin and Evolution of Life
Plant Water Relation
- Properties of Water
- Water Absorbing Organ
- Water Available to Roots for Absorption
- Diffusion
- Osmosis
- Imbibition
- Osmotic Pressure
- Water Potential (ψ)
- Turgidity and Flaccidity (Plasmolysis)
- Path of Water Across the Root
- Mechanism of Absorption of Water
- Translocation of Water
- Root Pressure Theory (Vital Theory)
- Capillarity Theory (physical force theory)
- Cohesion-Tension Theory (Transpiration pull theory)
- Transport of Mineral Ions
- Transportation of Food and Other Substances
- Concept of Transpiration
- Types of Transpiration > Cuticular Transpiration
- Types of Transpiration > Lenticular Transpiration
- Types of Transpiration > Stomatal Transpiration
- Structure of Stomatal Apparatus
- Significance of Transpiration
- Overview of Plant Water Relation
Plant Growth and Mineral Nutrition
- Plant Growth
- Phases of Plant Growth
- Conditions for Plant Growth
- Plant Growth Rate
- Types of Plant Growth
- Plant Growth Curve
- Differentiation, De-differentiation, Re- Differentiation
- Plant Development
- Plant Plasticity
- Plant Hormones
- Auxins
- Gibberellins
- Cytokinins
- Ethylene
- Abscisic Acid (ABA)
- Photoperiodism
- Vernalization (Yarovization)
- Plant Mineral Nutrition
- Roles of Mineral Elements in Plants
- Minerals Salt Absorption
- Nitrogen Cycle
- Overview of Plant Growth and Mineral Nutrition
Respiration and Circulation
- Respiration
- Gaseous Exchange in plants
- Respiration in Animals
- Human Respiratory System
- Mechanism of Respiration > Breathing
- Mechanism of Respiration > External Respiration
- Mechanism of Respiration > Internal Respiration
- Cellular Respiration
- Regulation of Breathing / Respiration
- Disorders of Respiratory System
- Transportation in Living Organisms
- Circulation in Animals
- Circulatory System Or Blood Vascular System
- Composition of Blood > Cellular Elements: Red Blood Cells (Erythrocytes)
- Composition of Blood > Cellular Elements: White Blood Cells (Leukocytes)
- Composition of Blood > Cellular Elements: Blood Platelets (Thrombocytes)
- Human Heart
- Working Mechanism of Human Heart
- Blood Vessels
- Blood Pressure (B.P.)
- Electrocardiogram (ECG)
- Lymph and Lymphatic System
- Overview of Respiration and Circulation
Control and Co-ordination
- Need for Control and Coordination in Organisms
- Nervous System in Hydra
- Nervous System in Planaria (Flatworm)
- Neural Tissue
- Synapse
- Transmission and Generation of Nerve Impulse
- Central Nervous System (CNS)
- The Human Brain
- The Spinal Cord
- Peripheral Nervous System (PNS)
- Reflex Action
- Autonomic Nervous System (ANS)
- Sensory Receptors
- Human Eye
- Structure of the Eyeball
- Human Ear
- Internal Ear and the Mechanism of Balance
- Disorders of Nervous System
- Human Endocrine System
- Concept of Hormone
- General Properties of Hormones
- Mechanism of Hormone Action
- The Hypothalamus
- Pituitary Gland or Hypophysis Gland
- The Pineal Gland
- Thyroid Gland
- Parathyroid Gland
- Thymus Gland
- Adrenal Gland (Suprarenal Gland)
- Pancreas (Islets of Langerhans)
- Reproductive Glands (Gonads)
- Diffuse Endocrine Glands
- Overview of Control and Co-ordination
Human Health and Diseases
- Health
- The Immune System
- Immunity
- Types of Immunity > Innate Immunity
- Types of Immunity > Acquired Immunity
- Cells of Immune System
- Vaccination and Immunization
- Structure of Antibody
- Formation of Antigen-Antibody Complex
- Blood Transfusion and Blood Groups (ABO and Rh system)
- Disease
- Diseases Caused by Protozoa > Malaria
- Diseases Caused by Protozoa > Amoebiasis (Amoeboic dysentery)
- Diseases Caused by Helminths > Ascariasis
- Diseases Caused by Helminths > Filariasis (Elephantiasis)
- Diseases Caused by Bacteria > Typhoid
- Diseases Caused by Bacteria > Pneumonia
- Diseases Caused by Viruses > Common Cold
- Diseases Caused by Fungi > Ringworm
- Diseases Caused by Viruses > Dengue Fever
- Cancer
- Types of Cancer
- Causes of Cancer
- Organs Commonly Affected by Cancer
- Prevention/Treatment of Cancer
- Acquired Immuno Deficiency Syndrome (AIDS)
- Concept of Adolescence
- Addiction
- Drug Abuse
- Addiction and Dependence
- Effects of Drug and Alcohol Abuse
- Prevention and Control of Drugs and Alcohol Abuse
- Overview of Human Health and Diseases
Human Reproduction
Enhancement of Food Production
- Improvement in Food Production
- Plant Breeding
- Hybridization and its Technique
- Mutation Breeding
- Tissue Culture
- Single Cell Protein (SCP)
- Biofortification
- Animal Husbandry (Livestock)
- Animal Husbandry (Livestock) > Animal Breeding
- Animal Husbandry (Livestock) > Dairy (Livestock) Farm Management
- Animal Husbandry (Livestock) > Poultry Farm Management
- Animal Husbandry (Livestock) > Apiculture (Bee Farming)
- Animal Husbandry (Livestock) > Pisciculture (Fish Farming)
- Animal Husbandry (Livestock) > Sericulture
- Animal Husbandry (Livestock) > Lac Culture
- Microbes in Human Welfare
- Microbes in Industrial Products
- Microbes in Sewage Treatment
- Microbes in Energy Generation
- Microbes as Biocontrol Agents
- Microbes as Biofertilizers
- Microbial Role in Dairy Products
- Overview of Enhancement of Food Production
Biotechnology
- Concept of Biotechnology
- Principles of Processes of Biotechnology
- Technique of Gene Cloning and rDNA Technology
- Methodology for rDNA Technology
- Applications of Biotechnology in Health and Medicine
- Applications of Biotechnology in Agriculture
- Gene Therapy
- Crop Biotechnology > Genetically Modified Organisms (GMOs)
- Transgenic Plants
- Transgenic Animals
- Bioethics
- Effects of Biotechnology on the Environment
- Effects of Biotechnology on Human Health
- Biopatent
- Biopiracy
- Overview of Biotechnology
Organisms and Populations
- Organisms and Their Environment
- Habitat
- Niche
- Habitat Vs Niche
- Climatic Factors > Temperature
- Climatic Factors > Precipitation
- Climatic Factors > Light
- Soil Factors (Edaphic Factors)
- Adaptations
- Population
- Population Age Distribution
- Population Growth
- Population Interactions
- Positive Interactions > Mutualism (Symbiosis)
- Negative Interactions > Competition
- Negative Interactions > Parasitism
- Negative Interactions > Predation
- Positive Interactions > Commensalism
- Overview of Organisms and Populations
Ecosystems and Energy Flow
Biodiversity, Conservation and Environmental Issues
- Biodiversity
- Levels of Biodiversity
- Patterns of Biodiversity
- Importance of Species Diversity to the Ecosystem
- Biodiversity Current Scenario
- Loss of Biodiversity
- Threatened Species
- Conservation of Biodiversity
- Biodiversity Conservation Methods
- Biological Diversity Act, 2002
- Environmental Issues
- Air Pollution
- Effects of Air Pollution
- Major Air Pollutants
- Prevention and Control of Air Pollution
- Noise Pollution
- Water Pollution
- Sources of Water Pollution
- Prevention and Control of Water Pollution
- Solid Waste Management
- Greenhouse Effect
- Global Warming
- Ozone Layer Depletion
- Deforestation and Its Causes
- Mission Harit Maharashtra
- Overview of Biodiversity, Conservation and Environmental Issues
Estimated time: 15 minutes
CBSE: Class 12
Maharashtra State Board: Class 10, 12
CISCE: Class 12
Maharashtra State Board: Class 10, 12
CISCE: Class 12
Definition: Triplet Codon
A sequence of three nucleotides on mRNA that codes for a specific amino acid is called a triplet codon.
CBSE: Class 12
Maharashtra State Board: Class 10, 12
CISCE: Class 12
Maharashtra State Board: Class 10, 12
CISCE: Class 12
Definition: Translation
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12
Concept of translation
Translation is the process by which the information present in messenger RNA is decoded to synthesise a polypeptide or protein. In this process, the sequence of codons on mRNA determines the sequence of amino acids in the protein formed. It is a major step of the central dogma, in which genetic information flows from DNA to RNA and then to protein.
-
Basis of coding
The message for protein synthesis is written on mRNA in the form of codons. Each codon is a triplet of nucleotides, and each triplet specifies a particular amino acid or a signal during translation. -
Role of mRNA
mRNA acts as the template for translation. It carries the genetic message copied from DNA and presents it to the ribosome in a readable codon sequence. -
Role of tRNA
tRNA functions as the adaptor molecule in translation. It brings specific amino acids to the ribosome and recognises codons on mRNA through complementary anticodons. -
Role of Ribosome
Ribosomes are the site of protein synthesis. They hold mRNA and tRNA in the correct position and help in the formation of peptide bonds between amino acids. -
Requirement of amino acid activation
Before translation proceeds, amino acids are activated and linked to their corresponding tRNA molecules. This charging of tRNA is necessary for correct amino acid delivery during protein synthesis. -
Sites of ribosome
The ribosome provides functional sites for the movement and positioning of tRNA during translation. These include the A site for incoming aminoacyl tRNA, the P site for peptidyl tRNA, and the E site for exit of empty tRNA.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12
Requirements for Translation
| Component | Role in Translation |
|---|---|
| mRNA | Carries the codon sequence to be read by the ribosome. |
| tRNA | Brings specific amino acids and matches anticodon with codon. |
| Ribosome | Site of protein synthesis; contains A, P, and E functional sites. |
| Amino acids | Raw materials for polypeptide formation. |
| Aminoacyl-tRNA synthetase | Activates amino acids and attaches them to the correct tRNA. |
| ATP/GTP | Supply energy during activation and translation steps. |
| Mg2+ ions and factors | Help maintain ribosomal structure and translation efficiency. |
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12
Stages of Translation
Translation
| Stage | Details |
|---|---|
| Initiation | - Translation begins when the ribosome binds to mRNA. - The small ribosomal subunit associates with the mRNA first. - The start codon is usually AUG. - The initiator tRNA recognises the start codon and binds to it. - This initiator tRNA carries methionine. - After this, the large ribosomal subunit joins, and the initiation complex is formed. |
| Elongation | - In this stage, amino acids are added one by one to the growing polypeptide chain. - Charged tRNAs bring specific amino acids to the ribosome according to the codons present on mRNA. - Codon-anticodon pairing ensures that the correct amino acid is placed in sequence. - Peptide bonds are formed between adjacent amino acids. - The ribosome moves forward on the mRNA by one codon at a time; this is called translocation. - As this process repeats, the polypeptide chain becomes longer. |
| Termination | - Translation ends when the ribosome reaches a stop codon on the mRNA. - The stop codons are UAA, UAG, and UGA. - These codons do not code for any amino acid. - Release factors bind when the stop codon is reached. - The completed polypeptide chain is released from the ribosome. - The ribosomal subunits then separate, ending the process. |
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12
Key Points: Translation
- Translation is the process by which the codon sequence on mRNA is decoded with the help of tRNA at the ribosome to form a specific sequence of amino acids in a protein.
- It needs mRNA (template), tRNA (adapter), ribosome (with A, P, and E sites), amino acids, aminoacyl-tRNA synthetase, ATP/GTP for energy, and Mg²⁺ ions.
- Before translation, amino acids are activated and linked to their specific tRNAs (charging) by aminoacyl-tRNA synthetase.
- Initiation: the small ribosomal subunit binds mRNA at the start codon (AUG), the initiator tRNA carrying methionine attaches, and the large subunit joins to form the initiation complex.
- Elongation: amino acids are added one by one through codon–anticodon pairing, peptide bonds form between them, and the ribosome moves forward by one codon at a time (translocation).
- Termination occurs at a stop codon (UAA, UAG, UGA), where release factors free the polypeptide and the ribosomal subunits separate.
