मराठी

Production of Lymphocytes - Humoral Immune Response (Response of B-Cells to Antigens)

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Estimated time: 3 minutes
CISCE: Class 12

Key Points: Humoral immune response (Response of B-cells to antigens)

  • The humoral immune response is driven by specific B lymphocytes that are individually programmed to recognise a single, distinct antigen.
  • Instead of continuously circulating, B-lymphocytes primarily settle in lymphoid tissues like the spleen and lymph nodes to encounter antigens processed by macrophages.
  • Upon activation, these B-lymphocytes transform into plasmablasts, which then multiply and differentiate into antibody-producing plasma cells.
  • A specific fraction of these activated cells becomes long-lasting memory cells, remaining in the lymphoid tissue to provide ongoing immunity.
  • Plasma cells release antibodies either directly at the site of infection or into lymphoid tissues, where they are transported by the blood and lymphatic systems.
  • Secreted antibodies bind to their target antigens to form a complex, triggering antigen destruction through direct neutralisation, opsonisation, or complement activation.
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