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Genetic Code - Chain Initiation and Chain Termination Codons

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Estimated time: 3 minutes
CISCE: Class 12

Key Points: Chain initiation and chain termination codons

Feature Chain Initiation Codons Chain Termination Codons
Designated Codons AUG, GUG UAA, UAG, UGA
Internal Cistron Coding Codes for methionine (AUG) and valine (GUG) when located between the ends of a cistron. Do not code for any of the 20 essential amino acids (classified as non-sense codons).
Context-Specific Rule When GUG is used as the initiating codon, it codes for formylated methionine instead of valine. When occurring immediately before AUG or GUG, they trigger the release of the chain.
Primary Function Signals the start of the message for the synthesis of a polypeptide chain. Signals the end of a message for the synthesis of a polypeptide chain.
Effect on Ribosome Acts as the starting point on the ribosome for building the polypeptide chain. Causes the direct release of the completed polypeptide chain from the ribosome.
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