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Leading Strand Vs Lagging Strand

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Estimated time: 3 minutes
CISCE: Class 12

Key Points: Leading Strand vs Lagging Strand

Feature Leading Strand Lagging Strand
Synthesis Type Continuous growth as a single piece without gaps. Discontinuous growth in short segments (Okazaki fragments).
DNA Ligase Not required. Required to join Okazaki fragments.
Growth Direction 5′ to 3′ direction. Overall 3′ to 5′ direction (fragments are synthesized 5′ to 3′).
Primer Requirement Requires only a single RNA primer. Requires a new RNA primer for each Okazaki fragment.
Synthesis Speed Rapid process. Slower process.
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