Linkage and Recombination

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Notes

Linkage and Recombination:  

Term linkage was given by. T.H. Morgan (Father of Experimental Genetics). T.H. Morgan conducted different experiments to understand the process of linkage and recombination. He carried out several dihybrid crosses in Drosophila to study genes that were sex-linked. For example, Morgan hybridized yellow-bodied, White-eyed females to brown-bodied, red-eyed males and intercrossed those F1 progeny. He observed that the two genes did not segregate independently of each other and the F2 ratio deviated very significantly from the 9:3:3:1 ratio (expected when the two genes are independent). 

  • Linkage: Physical association of genes on a chromosome. 
  • Recombination: Generation of non-parental gene combinations. 
  • According to Morgan: In the same chromosome, genes which are tightly linked will show very low recombination, i.e., variation and vice-versa. 
  • Alfred Sturtevant used the frequency of recombination between gene pairs on the same chromosome as a measure of the distance between genes and mapped their position on the chromosome.
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