English

Linkage and Recombination

Advertisements

Topics

Estimated time: 5 minutes
CBSE: Class 12

Definition: Linkage

The physical association of two or more genes located on the same chromosome, due to which they tend to be inherited together and do not assort independently, is called linkage.

CBSE: Class 12

Definition: Recombination

The process by which new (non-parental) combinations of genes are produced due to exchange of genetic material between homologous chromosomes during meiosis, is called recombination.

CBSE: Class 12

Key Points: Linkage and Recombination

  • Linkage - physical association of two or more genes on the same chromosome; linked genes do not assort independently.
  • Recombination - generation of non-parental gene combinations due to crossing over between linked genes.
  • Morgan's dihybrid crosses in Drosophila showed the F₂ ratio deviated from 9:3:3:1; genes were located on the X chromosome.
  • Genes on the same chromosome show more parental combinations than non-parental (recombinant) types.
  • Tightly linked = low recombination (white & yellow = 1.3%); loosely linked = high recombination (white & miniature wing = 37.2%).
  • Alfred Sturtevant (Morgan's student) used recombination frequency to measure gene distance and create chromosome maps, now used in Human Genome Sequencing.
Advertisements
Share
Notifications

Englishहिंदीमराठी


      Forgot password?
Use app×