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Human Genome Project

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Estimated time: 5 minutes
Maharashtra State Board: Class 12
CISCE: Class 12

Key Points: Human Genome Project

  • The Human Genome Project (HGP) was an international mega project launched in 1990 and completed in 2003 to sequence the entire human genome.
  • It was coordinated mainly by the US Department of Energy and the National Institutes of Health (NIH), with participation from about 18 countries.
  • The main aim was to identify all human genes, determine their locations, and sequence the complete human DNA (about 3.2 billion base pairs).
  • The human genome contains approximately 20,000–25,000 genes, and less than 2% of DNA codes for proteins, while most consists of non-coding and repetitive sequences.
  • The project used advanced techniques like automated DNA sequencing, cloning using BAC and YAC vectors, and genome mapping approaches.
  • HGP revealed that about 99.9% of human DNA is identical, with variations such as SNPs and CNVs responsible for individual differences.
  • The project has applications in disease diagnosis, gene therapy, genetic counselling, and understanding human evolution, along with ethical concerns related to genetic data use.

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