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Mutations and Genetic Code

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CBSE: Class 12

Key Points: Mutations and Genetic Code

  • Mutation studies help explain the relationship between genes and DNA; large mutations cause loss or gain of genes, while point mutations affect single base pairs.
  • A point mutation in the β-globin gene (glutamate replaced by valine) causes the genetic disorder sickle-cell anaemia.
  • Insertion or deletion of one or two bases shifts the reading frame of codons, producing frameshift mutations.
  • Insertion or deletion of three or multiples of three bases removes or adds whole codons, so the reading frame remains unchanged.
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