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Applications of Biotechnology in Health and Medicine

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Estimated time: 7 minutes
CISCE: Class 12

Key Points: Vaccine Production

  • Vaccines produced using recombinant DNA technology are called recombinant or subunit vaccines, such as the hepatitis-B vaccine.
  • These vaccines may be protein vaccines (using specific antigens) or DNA vaccines that induce an immune response.
  • Examples include hepatitis-B vaccine produced in yeast, rotavirus, dengue, HPV vaccines, and plant-based edible vaccines.
CISCE: Class 12

Key Points: Genetically Engineered Insulin

  • Earlier insulin was obtained from animals, which caused allergic reactions and could not meet large-scale demand.
  • Recombinant DNA technology enabled large-scale production of human insulin, first produced in 1983 as Humulin®.
  • Human insulin consists of two polypeptide chains (A and B) that are produced separately in E. coli using plasmid vectors.
  • The purified A and B chains are joined by disulphide bonds to form active human insulin.
Maharashtra State Board: Class 12

Key Points: Applications of Biotechnology in Health and Medicine

  • Biotechnology has wide applications in healthcare, agriculture, industry, the environment, and genomics.
  • In healthcare, it provides diagnostic and therapeutic solutions such as stem cell therapy, genetic counselling, DNA fingerprinting, and gene probes.
  • Human insulin is produced using recombinant DNA technology by inserting insulin genes into bacteria like E. coli.
  • Biotechnology helps in the production of vaccines using weakened or modified microorganisms to provide immunity against diseases.
  • Advanced vaccines include recombinant vaccines, DNA vaccines, and plant-based (edible) vaccines.
  • Oral and “melt-in-the-mouth” vaccines are modern innovations that are easy to administer and cost-effective.
  • Biotechnology has significantly helped in controlling diseases like smallpox and polio and is advancing towards treating major diseases like cancer.

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