हिंदी
Karnataka Board PUCPUC Science 2nd PUC Class 12

Diseases Caused by Bacteria > Typhoid

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Estimated time: 14 minutes
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Introduction

Typhoid is a highly infectious bacterial disease of the intestine caused by Salmonella typhi.

It is an enteric fever affecting the intestines.

Causative Organism:

  • The causative organism is Salmonella typhi.
  • It is a Gram-negative bacterium.
  • Its pathogenicity is due to the O antigen, and its flagella contain the H antigen.

Entry and Spread in Body:

  • The bacteria enter the body through contaminated food and water.
  • They reach the small intestine and may migrate to other organs through the blood.

Salmonella typhi

CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Symptoms

  • Sustained or prolonged high fever, usually 39–40°C or up to 104°F.
  • Headache and weakness.
  • Abdominal pain or stomach pain.
  • Constipation; diarrhoea may also occur.
  • Loss of appetite, nausea, fatigue, and severe body pain.
  • A rose-coloured rash, a white-coated tongue, and a cough may be present.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Severe Effects

  • Intestinal perforation may occur in severe cases.
  • Haemorrhage, breathlessness, irregular heartbeat, and death may occur if untreated.
  • Relapse may occur about two weeks after apparent recovery.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Diagnosis and Treatment

Diagnosis:

  • Typhoid is confirmed by the Widal test.
  • Blood, urine, and faeces may also be tested for confirmation.

Treatment:

  • Antibiotics are used in treatment.
  • The patient may be isolated.
  • Proper nursing care and frequent fluids are advised.
  • In severe cases, surgical removal of the gallbladder may be required.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Spread of Infection

  • The disease spreads through contaminated food and water.
  • Houseflies and cockroaches may transfer the bacteria from faecal matter to food.
  • Poor hygiene and sanitation contribute to its spread.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Carrier State

  • Some recovered persons become carriers.
  • Such persons harbour the bacteria in their intestines and excrete them in their faeces.
  • They may remain infectious without showing symptoms.
  • Mary Mallon, known as Typhoid Mary, is a classic example.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Prevention

  • Proper sanitation is necessary.
  • Open food should be avoided.
  • Hygienic food and safe water should be used.
  • Immunisation helps in prevention.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Vaccination

  • The oral Ty21a vaccine is mentioned.
  • Injectable typhoid polysaccharide vaccine is also mentioned.
  • TAB vaccine provides immunity for about 3 years.
CBSE: Class 12
Maharashtra State Board: Class 12
CISCE: Class 12

Key Points: Typhoid

Aspect Details
Disease & Type Typhoid – a highly infectious bacterial enteric fever of the intestine
Causative organism Salmonella typhi - Gram-negative bacterium; pathogenicity due to O antigen; flagella have H antigen
Mode of spread Contaminated food and water, houseflies and cockroaches transfer bacteria from faeces to food
Symptoms Prolonged high fever (39–40°C / up to 104°F), headache, weakness, abdominal pain, constipation or diarrhoea, loss of appetite, rose-coloured rash, white-coated tongue
Severe effects Intestinal perforation, haemorrhage, breathlessness, irregular heartbeat, and death if untreated
Diagnosis Widal test; blood, urine, and faeces tests
Treatment Antibiotics, isolation, fluids, and gall bladder surgery in severe cases
Prevention Sanitation, hygienic food, safe water, and avoid eating open food
Vaccination Oral Ty21a, injectable polysaccharide, TAB (~3 years' immunity)
Carrier state Recovered persons may carry bacteria in the intestine without symptoms – e.g., Typhoid Mary (Mary Mallon)
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