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Question
Write a short note on the following:
Gabriel phthalimide synthesis
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Solution
Gabriel synthesis is used for the preparation of primary amines. Phthalimide, on treatment with ethanolic potassium hydroxide, forms potassium salt of phthalimide, which on heating with alkyl halide followed by alkaline hydrolysis, produces the corresponding primary amine. Aromatic primary amines cannot be prepared by this method because aryl halides do not undergo nucleophilic substitution with the anion formed by phthalimide.
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\[\begin{array}{cc}
\ce{O}\phantom{.........}\\
||\phantom{.........}\\
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\ce{O}\\
||\\
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Write a short note on the following
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Write a short note on the following.
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Write a short note on the following.
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