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प्रश्न
Answer the following
Explain Gabriel phthalimide synthesis.
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उत्तर
This method is used for the synthesis of primary amine. It involves the following three stages.
i. Formation of the potassium salt of phthalimide from phthalimide on reaction with alcoholic potassium hydroxide.
ii. Formation of N-alkyl phthalimide from the potassium salt by reaction with an alkyl halide.
iii. Alkaline hydrolysis of N-alkyl phthalimide to form the corresponding primary amine.
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संबंधित प्रश्न
Write a short note on Hoffmann bromamide degradation.
Identify the compounds 'A' and 'B' in the following equation:
Give the structure of A, B and C in the following reaction:
\[\ce{C6H5N2Cl ->[CuCN] A ->[H2O/H+] B ->[NH3][\Delta] C}\]
Give the structure of A, B and C in the following reaction:
\[\ce{CH3CH2Br ->[KCN] A ->[LiAlH4] B ->[HNO2][0^\circ C] C}\]
Write the reaction of aromatic primary amine with nitrous acid.
Give a plausible explanation for the following:
Why are amines less acidic than alcohols of comparable molecular masses?
Arrange the following in the increasing order of their pKb values:
C6H5NH2, C2H5NH2, C6H5NHCH3
Write structures of compounds A and B in each of the following reactions:
Answer in one sentence.
Which amide does produce ethanamine by Hofmann bromamide degradation reaction?
Answer in one sentence.
Predict the product of the following reaction.
\[\ce{Nitrobenzene ->[Sn/conc.HCl]?}\]
Answer the following
Explain the ammonolysis of alkyl halides.
Mendius reaction is used to convert _____________
Write reactions to bring about the following conversions.
Acetamide to Ethylamine
Write reactions for the preparation of ethanamine using Gabriel phthalimide synthesis.
Why cannot aniline be prepared by Gabriel phthalimide synthesis?
Explain the following reaction with a suitable example.
Hofmann elimination reaction
Identify the product obtained, when benzamide is treated with bromine and aqueous sodium hydroxide.
Identify the major product (B).
____________ can be prepared exclusively by Gabriel phthalimide synthesis.
What is the molar mass of the amine formed when acetamide undergoes Hofmann bromamide degradation?
\[\ce{CH3-CN ->[Na/C2H5OH]}\]
The product formed is ____________.
Which of the following amines forms a clear solution when treated with benzene sulphonyl chloride and excess of potassium hydroxide?
The reduction of alkyl cyanide with sodium and ethanol to give primary amines is, ____________.
Identify 'A' and 'B' in the following conversions.
\[\ce{CH3 - I ->[Alc. KCN][\Delta] A ->[Na/C2H5OH] B}\]
Which of the following reagents is used in Mendius reduction reaction of alkyl cyanide?
Which of the following does NOT give carbylamine test?
Nitro compounds are reduced by iron scrap and hydrochloric acid to yield one of the following compounds:
Quaternary ammonium salt is formed:
Given below are two statements labelled as Assertion (A) and Reason (R).
Assertion (A): Alkyl halides are insoluble in water.
Reason (R): Alkyl halides have halogen attached to sp3 hybrid carbon.
Select the most appropriate answer from the options given below:
Which of the following reagents would not be a good choice for reducing an aryl nitro compound to an amine?
Amongst the given set of reactants, the most appropriate for preparing 2° amine is ______.
Reduction of aromatic nitro compounds using \[\ce{Fe}\] and \[\ce{HCl}\] gives ______.
Which of the following methods of preparation of amines will give same number of carbon atoms in the chain of amines as in the reactant?
Which of the following amines can be prepared by Gabriel synthesis.
(i) Isobutyl amine
(ii) 2-Phenylethylamine
(iii) N-methylbenzylamine
(iv) Aniline
Which of the following reactions are correct?
(i)
(ii)
(iii)
(iv)
Identify A and B in the following reaction.
Write following conversions:
nitrobenzene `->` acetanilide
Write following conversions:
acetanilide `->` p-nitroaniline
How will you carry out the following conversions?
Assertion: Hoffmann’s bromamide reaction is given by primary amines.
Reason: Primary amines are more basic than secondary amines.
Describe Gabriel's phthalimide synthesis. (Give reaction)
Account for the following:
Aniline cannot be prepared by the ammonolysis of chlorobenzene under normal conditions.
A primary amine is formed by an amide on treatment with bromine and alkali. The primary amine has
Ethylamine can be prepared by the action of bromine and caustic potash on which compound?
In the given reaction what is the X?
\[\begin{array}{cc}
\ce{O}\phantom{.......................}\\
||\phantom{.......................}\\
\phantom{}\ce{R - C - OH <-[H3O] Χ ->[H] RCH2NH2}
\end{array}\]
Which of the following CANNOT be prepared by ammonolysis of alkyl halide?
Which of the following amines can be prepared by Gabriel phthalimide reaction?
The amine 'A' when treated with nitrous acid gives yellow oily substance. The amine A is ______.
What is the IUPAC name of \[\ce{(CH3)2 - N - CH3}\]?
Identify A and B in the following reaction.
\[\ce{C6H5CH2Br ->[Alco.][KCN] A ->[Na/Ethanol][reduction] B}\]
Write short note on the following:
Ammonolysis
Assertion: Amimonolysis of alkyl halides involves the reaction between alkyl halides and alcoholic ammonia.
Reason: Ammonolysis of alkyl halides produces secondary amines only.
