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Questions
What would be the molar concentration of human DNA in a human cell?
What would be the molar concentration of human DNA in a human cell? Consult your teacher.
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Solution
Human diploid cell contains about 6 × 10–12 g DNA.
Human genome size ≈ 6.4 × 109 base pairs
Average mass of 1 base pair ≈ 660 g mol–1
Molar mass of DNA = 6.4 × 109 × 660
= 4.2 × 1012 g mol–1
Moles of DNA per cell = `(6xx10^-12)/(4.2xx10^12)`
= 1.4 × 10–24 mol
Taking average cell volume = 10–12 L
Concentration = `(1.4xx10^-24)/10^-12`
= 1.4 × 10–12 M
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