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Genetic Code - tRNA – the Adapter Molecule

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Estimated time: 3 minutes
Maharashtra State Board: Class 12

Key Points: tRNA – the Adapter Molecule

  • tRNA (transfer RNA) is called the adapter molecule because it links mRNA codons to their corresponding amino acids during the process of translation.
  • The structure of tRNA resembles a cloverleaf in 2D (with loops and arms) and a hairpin/L-shape in 3D. It has two important sites — the anticodon loop (for codon recognition on mRNA) and the amino acid attachment site at the 3' end (acceptor end).
  • tRNA has the following main structural parts: Acceptor arm (3' end, carries amino acid), TΨC arm/loop, DHU arm/loop, Anticodon arm with anticodon loop (recognises mRNA codon), and a Variable loop.
  • The anticodon present on tRNA is complementary to the codon on mRNA. This ensures the correct amino acid is added during protein synthesis.
  • The 3' end of tRNA always ends with the sequence CCA, where the amino acid attaches. The 5' end starts with G. Hydrogen bonds hold the structure together.
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