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Question
With the help of suitable diagrams, explain the five stages of prophase-I of meiosis.
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Solution
Prophase-I is the first stage of meiosis-I and is the longest and most important stage. It is divided into five sub-stages:
1. Leptotene
- Chromosomes begin to condense.
- They become long, thin, and distinct.

2. Zygotene
- Homologous chromosomes pair together by a process called synapsis.
- A synaptonemal complex is formed.
- Paired chromosomes form bivalents or tetrads.

3. Pachytene
- It is the longest stage of Prophase-I.
- Chromosomes become shorter and thicker.
- Crossing over occurs between non-sister chromatids of homologous chromosomes.
- Recombination nodules appear at crossing-over sites

4. Diplotene
- Synaptonemal complex dissolves.
- Homologous chromosomes begin to separate.
- Chiasmata appear at crossover points.

5. Diakinesis
- Chiasmata terminalise.
- Chromosomes condense further.
- The nuclear membrane and nucleolus disappear.
- Meiotic spindle fibres begin to form.

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