Advertisements
Advertisements
Question
C-peptide of human insulin is ______.
Options
A part of mature insulin molecule
Responsible for the formation of disulphide bridges
Removed during maturation of pro-insulin to insulin
Responsible for its biological activity.
Advertisements
Solution
C-peptide of human insulin is removed during maturation of pro-insulin to insulin.
Explanation:
Insulin is synthesized as a pro-hormone in mammals, including humans, and must be processed before it becomes a fully developed and functioning hormone. It has an additional stretch, known as the C-peptide, which is removed during insulin maturation.
RELATED QUESTIONS
Explain enzyme – replacement therapy to treat adenosine deaminase deficiency. Mention two disadvantages of this procedure.
How did an American Company, Eli Lilly use the knowledge of r-DNA technology to produce human insulin?
Expand the Given and mention one application of each:
PCR
What is gene therapy? Illustrate using the example of adenosine deaminase (ADA) deficiency.
Consult the internet and find out how to make orally active protein pharmaceuticals. What is the major problem to be encountered?
Expand the Given and mention one application of each:
ELISA
Explain how insulin can be produced using recombinant DNA technology.
State the best-known contribution of P.K. Sethi
Answer the following question.
Describe the roles of heat, primers, and the bacterium Thermus aquaticus in the process of PCR.
Answer the following question.
Explain the various steps involved in the production of artificial insulin.
Describe the role of high temperature.
Mention the number of primers required in each cycle of PCR. Write the role of primers and DNA polymerase in PCR. Name the source organism of the DNA polymerase used in PCR.
What is genetically engineered Insulin?
ELISA technique is based on the principles of antigen-antibody interaction. Can this technique be used in the molecular diagnosis of a genetic disorder, such as phenylketonuria?
What are DNA vaccines?
Explain how recombinant Insulin can be produced.
Human insulin is being commercially produced forma transgenic species of ______.
A pathophysiology is the ______.
Due to which of the following reasons insulin extracted from pancreas of slaughtered animals cannot be used in humans to treat diabetes?
Which of the following is not an application of PCR (Polymerase Chain Reaction)?
Now a days it is possible to detect the mutated gene causing cancer by allowing a radioactive probe to hybridize its complimentary DNA in a clone of cells, followed by its detection using autoradiography because ______
Give the full form of ELISA. Which disease can be detected using it? Discuss the principle underlying the test.
Who was the first patient who was given gene therapy? Why was the given treatment recurrent in nature?
Define Antigen and Antibody. Name any two diagnostic kits based upon them.
When a foreign DNA is introduced into an organism, how is it maintained in the host and how is it transferred to the progeny of the organism?
The diagram given below represents the schematic structure of proinsulin, which undergoes certain modifications before it becomes a fully functional insulin.
Study the diagram carefully and answer the questions that follow:

- State the change the proinsulin undergoes to become fully functional.
- Name the modern scientific technique used for the production of human insulin.
- How are the two polypeptide chains of the fully functional insulin held together?
The ______ gene from Bacillus thuringiensis produces a protein that forms crystalline inclusions in bacterial spores.
