Advertisements
Advertisements
Question
How is a mature, functional insulin hormone different from its prohormone form?
Advertisements
Solution
Mature functional insulin is obtained by processing pro-hormone which contains an extra peptide called C-peptide. This C-peptide is removed during the maturation of pro-insulin to insulin.
APPEARS IN
RELATED QUESTIONS
State the best-known contribution of P.K. Sethi
If a person thinks he is infected with HIV, due to unprotected sex, and goes for a blood test. Do you think a test such as ELISA will help? If so why? If not, why?
The hormone insulin is secreted by:
Now a days it is possible to detect the mutated gene causing cancer by allowing a radioactive probe to hybridize its complimentary DNA in a clone of cells, followed by its detection using autoradiography because ______
Can a disease be detected before its symptoms appear? Explain the principle involved.
Discuss briefly how a probe is used in molecular diagnostics.
List the disadvantages of insulin obtained from the pancreas of slaughtered cows and pigs:
List the advantages of recombinant insulin.
A cell-free method of amplifying DNA first developed in the mid 1980's revolutionised the field of biotechnology, Name the method and explain the basic steps of the technique involved.
Explain how recombinant human insulin was prepared in 1983 by Eli Lily an American company.
- Assertion: PCR is a powerful technique to identify genetic disorders.
- Reason: PCR can detect mutations in low amounts of DNA.
The diagram given below represents the schematic structure of proinsulin, which undergoes certain modifications before it becomes a fully functional insulin.
Study the diagram carefully and answer the questions that follow:
- State the change the proinsulin undergoes to become fully functional.
- Name the modern scientific technique used for the production of human insulin.
- How are the two polypeptide chains of the fully functional insulin held together?
Name the technique used to detect the presence of HIV in the body of an individual, Justify the principle associated with this technique.
The ______ gene from Bacillus thuringiensis produces a protein that forms crystalline inclusions in bacterial spores.
Globally, approximately how many recombinant therapeutics have been approved for human use, and how many of them are currently marketed in India?
Which of the following describes the final step in the laboratory synthesis of biologically active humulin from isolated chains?
Why is the Polymerase Chain Reaction (PCR) preferred over conventional culture and serological methods for early disease diagnosis?
