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Question
Differentiate between Leading stand and lagging strand.
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Solution
| Feature | Leading Strand | Lagging Strand |
| 1. Direction of synthesis | Synthesized continuously in the same direction as the replication fork. | Synthesized discontinuously in the opposite direction of the replication fork. |
| 2. Formation | Formed as a single, continuous strand. | Formed in short fragments called Okazaki fragments. |
| 3. Requirement of primers | Requires only one RNA primer to start synthesis. | Requires multiple RNA primers, one for each Okazaki fragment. |
| 4. DNA polymerase movement | Moves toward the replication fork. | Moves away from the replication fork. |
| 5. Speed of synthesis | Faster because it is continuous. | Slower because it is discontinuous. |
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