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Question
Differentiate between Leading stand and lagging strand.
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Solution
| Feature | Leading Strand | Lagging Strand |
| 1. Direction of synthesis | Synthesized continuously in the same direction as the replication fork. | Synthesized discontinuously in the opposite direction of the replication fork. |
| 2. Formation | Formed as a single, continuous strand. | Formed in short fragments called Okazaki fragments. |
| 3. Requirement of primers | Requires only one RNA primer to start synthesis. | Requires multiple RNA primers, one for each Okazaki fragment. |
| 4. DNA polymerase movement | Moves toward the replication fork. | Moves away from the replication fork. |
| 5. Speed of synthesis | Faster because it is continuous. | Slower because it is discontinuous. |
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Long Answer Question:
Explain the process of DNA replication.
Describe the process of semiconservative replication of DNA with the help of a neat and labelled diagram.
What is the basis for the difference in the synthesis of the leading and lagging strand of DNA molecules?
Which of the following statements is not true about DNA replication in eukaryotes?
a) Identify the figure given below
b) Redraw the structure as a replicating fork and label the parts
c) Write the source of energy for this replication and name the enzyme involved in this process.
d) Mention the differences in the synthesis of protein, based on the polarity of the two template strands.
Meselson and Stahl used ____________ in the experiment to prove semiconservative DNA replication.
For which of the following purpose agarose gel electrophoresis technique is used?
Complementary strands of DNA molecule are (i) and bound by (ii).
E. coli, in which both the strands of DNA are labeled with 15N is transferred to 14N medium and allowed to replicate for three generations. What would be the number of hybrid DNA molecules in the third generation?
Which of the following is present at the sticky ends of a fragmented DNA molecule?
Which of the following is the function of single-strand binding proteins?
Which one of the following can form a nucleotide of DNA?
When the DNA molecule appears like inverted Y, it is ______
Wobble position means:
Which of the following reaction is required for proofreading during DNA replication by DNA polymerase III?
Statement I - In prokaryotes, there is only replicon however in eukaryotes, these are several replicons in tandem.
Statement II - Two separated strands in a replicon of DNA are prevented from re-joining by helicase enzyme.
In light of above statements, choose the correct answer from the option given below.
Which phase of the cell cycle is DNA replication primarily restricted to?
