Question

Can Gatterman-Koch reaction be considered similar to Friedel Craft’s acylation? Discuss.

Answer 1

Gattermann-Koch reaction is formylation (introduction of-CHO group) to the benzene nucleus. Friedel-Crafts acylation reaction is introduction of RCO-group in the benzene ring.

In Friedel-Crafts acylation reactions, the benzene is treated with an acid chloride in presence of anhydrous \[\ce{AlCl3}\]. So, Gattermann-Koch reaction can be considered similar to Friedel-Crafts acylation reaction.