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Question
Write a short note on the following.
Hofmann’s bromide reaction
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Solution
When Amides are treated with bromine in the presence of an aqueous or ethanolic solution of KOH, primary amines with one carbon atom less than the parent amides are obtained.
\[\begin{array}{cc}
\ce{O}\phantom{............................................}\\
||\phantom{............................................}\\
\ce{\underset{\underset{(R = Alkyl (or) Aryl)}{(amide)}}{R - C - NH2} ->[Br2/KOH] \underset{(Primary amine)}{R - NH2 + K2 CO3} + KBr + H2O}
\end{array}\]
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