Advertisements
Advertisements
Question
Account for the following:
Gabriel phthalimide synthesis is not preferred for preparing aromatic primary amines.
Advertisements
Solution
Gabriel phthalimide synthesis not prefered for preparing aromatic primary amines because amine formation involves nucleophilic substituion 2 ( ) SN of alkyl halides by the anion formed by the phthalimide. But aryl halides do not undergo nucleophilic substitution with the anion formed by the phthalimide. As nucleophilic substitution reactions are very difficult in aryl halides.
APPEARS IN
RELATED QUESTIONS
Answer the following
Write a reaction to convert acetic acid into methylamine.
Answer the following
Explain Gabriel phthalimide synthesis.
The end product C of the following reaction is
\[\ce{C2H5NH2 ->[HNO2] A ->[PCl5] B ->[NH3][Alcohol] C}\]
Identify the major product (B).
\[\ce{CH3-CN ->[Na/C2H5OH]}\]
The product formed is ____________.
Which of the following reactions is appropriate for converting benzamide to aniline?
Identify product B in the following reaction.
\[\ce{Aniline ->[NaNO2][HCl] A ->[KI] B}\]
What is the best reagent to convert nitrile to primary amine?
Write a short note on the following:
Ammonolysis
Assertion: Amimonolysis of alkyl halides involves the reaction between alkyl halides and alcoholic ammonia.
Reason: Ammonolysis of alkyl halides produces secondary amines only.
