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प्रश्न
Why cannot aromatic primary amines be prepared by Gabriel phthalimide synthesis?
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उत्तर
Gabriel synthesis is used for the preparation of primary amines. Phthalimide, on treatment with ethanolic potassium hydroxide, forms potassium salt of phthalimide, which on heating with alkyl halide followed by alkaline hydrolysis produces the corresponding primary amine. Aromatic primary amines cannot be prepared by this method because aryl halides do not undergo nucleophilic substitution with the anion formed by phthalimide.
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संबंधित प्रश्न
Give the structures of A, B and C in the following reactions :
Give the structures of A, B and C in the following reactions :
Answer in one sentence.
Which amide does produce ethanamine by Hofmann bromamide degradation reaction?
The following amines is the product of Gabriel phthalimide synthesis.
Name the process of breaking C-X bond by ammonia in preparation of amines.
Which nitrogen containing compound amongst the following would undergo Mendius reduction to furnish primary amine \[\ce{(R - NH2)}\]?
Which of the following compounds is obtained when quaternary ammonium hydroxide is strongly heated?
Benzylamine may be alkylated as shown in the following equation:
\[\ce{C6H5CH2NH2 + R - X -> C6H5CH2NHR}\]
Which of the following alkylhalides is best suited for this reaction through SN1 mechanism?
Which of the following amines can be prepared by Gabriel synthesis.
(i) Isobutyl amine
(ii) 2-Phenylethylamine
(iii) N-methylbenzylamine
(iv) Aniline
How will you bring out the following conversion?
How will you carry out the following conversion?
Assertion: Hoffmann’s bromamide reaction is given by primary amines.
Reason: Primary amines are more basic than secondary amines.
Assertion: Aromatic 1° amines can be prepared by Gabriel Phthalimide Synthesis.
Reason: Aryl halides undergo nucleophilic substitution with anion formed by phthalimide.
A primary amine is formed by an amide on treatment with bromine and alkali. The primary amine has
Which of the following compound gives pink colour on reaction with phthalic anhydride in cone. H2SO4 followed by treatment with NaOH?
Write short note on the following.
Ammonolysis.
Assertion: Amimonolysis of alkyl halides involves the reaction between alkyl halides and alcoholic ammonia.
Reason: Ammonolysis of alkyl halides produces secondary amines only.
Write a short note on the following:
Ammonolysis
