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प्रश्न
Why cannot aromatic primary amines be prepared by Gabriel phthalimide synthesis?
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उत्तर
Gabriel synthesis is used for the preparation of primary amines. Phthalimide, on treatment with ethanolic potassium hydroxide, forms potassium salt of phthalimide, which on heating with alkyl halide followed by alkaline hydrolysis produces the corresponding primary amine. Aromatic primary amines cannot be prepared by this method because aryl halides do not undergo nucleophilic substitution with the anion formed by phthalimide.
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संबंधित प्रश्न
An aromatic compound 'A' of molecular formula C7H7ON undergoes a series of reactions as shown below. Write the structures of A, B, C, D and E in the following reactions :
Answer in one sentence.
Predict the product of the following reaction.
\[\ce{Nitrobenzene ->[Sn/conc.HCl]?}\]
Answer the following
Write a reaction to convert acetic acid into methylamine.
\[\ce{CH3-CN ->[Na/C2H5OH]}\]
The product formed is ____________.
The reduction of alkyl cyanide with sodium and ethanol to give primary amines is, ____________.
Which of the following reagents is used in Mendius reduction reaction of alkyl cyanide?
Benzylamine may be alkylated as shown in the following equation:
\[\ce{C6H5CH2NH2 + R - X -> C6H5CH2NHR}\]
Which of the following alkylhalides is best suited for this reaction through SN1 mechanism?
Which of the following amines can be prepared by Gabriel synthesis.
(i) Isobutyl amine
(ii) 2-Phenylethylamine
(iii) N-methylbenzylamine
(iv) Aniline
How will you carry out the following conversion?
How will you carry out the following conversion?
How will you carry out the following conversions?
Account for the following:
Aniline cannot be prepared by the ammonolysis of chlorobenzene under normal conditions.
Which of the following reactions will not give a primary amine?
Give reasons for the following:
Ammonolysis of alkyl halides is not a good method to prepare pure primary amines.
Which of the following amines can be prepared by Gabriel phthalimide reaction?
Write short note on the following:
Ammonolysis
Write short notes on the following:
Ammonolysis
