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Question
Write a note on coagulation of blood.
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Solution
- Clotting or coagulation is the process of converting the liquid blood into a solid form. This process may be initiated by contact of blood with any foreign surface (intrinsic process) or with damaged tissue (extrinsic process).
- Intrinsic and extrinsic processes involve interaction of various substances called clotting factors by a step wise or cascade mechanism.
- There are in all twelve clotting factors numbered as I to XIII (factor VI is not in active use). Interaction of these factors occurs in cascade manner leading to formation of the enzyme thrombin.
- Thromboplastin helps in the formation of enzyme prothrombinase. This enzyme inactivates heparin and it also converts inactive prothrombin into its active thrombin.
- Thrombin converts soluble blood protein fibrinogen into insoluble fibrin. Fibrin forms a mesh in which platelets and other blood cells are trapped to form the clot.
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