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Question
How does pepsinogen change into its active form?
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Solution 1
Pepsinogen is a precursor of pepsin stored in the stomach walls. It is converted into pepsin by hydrochloric acid. Pepsin is the activated in the form of pepsinogen.
Pepsinogen
Pepsin + Inactive peptide
(Inactive) (Active)
Solution 2
The proenzyme pepsinogen, on exposure to hydrochloric acid, secreted by oxyntic cells of gastric glands gets converted into the active enzyme pepsin, the proteolytic enzyme of the stomach.
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