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प्रश्न
Write short notes on acetylation.
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उत्तर
The process of introducing an acetyl group \[\begin{array}{cc}
\phantom{.....}\ce{O}\\
\phantom{.....}||\\
\ce{(CH3 - C - )}
\end{array}\] into a molecule is called acetylation. The reaction occurs by nucleophilic substitution. There occurs a replacement of the hydrogen atom of −NH2 or > NH by the acetyl group.
Common acetylating agents used are acetyl chloride and acetic anhydride.
\[\begin{array}{cc}
\ce{O}\phantom{................}\ce{O}\phantom{..}\\
||\phantom{.................}||\phantom{..}\\
\ce{CH3CH2NH2 + CH3 - C - Cl -> \underset{N-Ethylacetamide}{CH3 - C - NH - CH2CH3} + HCl}
\end{array}\]
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संबंधित प्रश्न
Write the structures of main products when aniline reacts with the following reagents :
Br2 water
Write the structures of main products when aniline reacts with the following reagents :
(CH3CO)2O/pyridine
Account for the following:
Although the amino group is o, p-directing in aromatic electrophilic substitution reactions, aniline on nitration gives a substantial amount of m-nitroaniline.
What is the action of acetic anhydride on diethylamine?
What is the action of the following reagents on aniline?
Hot and conc. sulphuric acid
How will you convert the following?
Aniline into N−phenylethanamide
In the nitration of benzene using a mixture of conc. \[\ce{H2SO4}\] and conc. \[\ce{HNO3}\], the species which initiates the reaction is ______.
What is the role of \[\ce{HNO3}\] in the nitrating mixture used for nitration of benzene?
Assertion: N, N-Diethylbenzene sulphonamide is insoluble in alkali.
Reason: Sulphonyl group attached to nitrogen atom is strong electron-withdrawing group.
When bromination of aniline is carried out by protecting – NH2. The major product is
Give reasons for the following observation:
Aniline is acetylated before nitration reaction.
Give reasons for the following observation:
Aniline does not react with methyl chloride in the presence of anhydrous AlCl3 catalyst.
How can the activating effect of the −NH2 group in aniline be controlled?
Assertion (A): Bromination of benzoic acid, gives m-bromobenzoic acid.
Reason (R): Carboxyl group increases the electron density at the meta position.
Identify the major product C formed in the following reaction sequence:
\[\ce{CH3 - CH2 - CH2 - I ->[NaCN] A ->[OH-][Partial hydrolysis] B ->[NaOH][Br2] \underset{(major)}{C}}\]
