हिंदी

Concentration of Urine

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Estimated time: 3 minutes
Maharashtra State Board: Class 12

Key Points: Concentration of Urine

  • Concentration of urine occurs by a counter-current mechanism involving Henle’s loop and vasa recta.
  • Osmotic gradient is maintained from cortex (300 mOsm/L) to medulla (up to 1200 mOsm/L) by NaCl and urea.
  • Descending limb of Henle’s loop is permeable to water, so water moves out and filtrate becomes concentrated.
  • Ascending limb is impermeable to water and actively transports Na⁺ and Cl⁻, making filtrate dilute.
  • ADH increases water reabsorption in collecting ducts, leading to formation of concentrated urine.
  • Urea recycling and vasa recta help maintain the osmotic gradient, enabling maximum water reabsorption.
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