Question

Which three post-transcriptional modifications convert hnRNA into mature mRNA in eukaryotes?

Options

• Phosphorylation, methylation, and acetylation

• Capping, tailing, and splicing

• Ubiquitination, sumoylation, and neddylation

• Oxidation, reduction, and hydrolysis

Answer 1

In eukaryotes, hnRNA undergoes three major post-transcriptional modifications: capping (addition of 7-methylguanosine cap at the 5' end), tailing (addition of poly-A tail at the 3' end), and splicing (removal of introns and joining of exons). These modifications are essential for mRNA stability, translation, and transport.