Question

What is the incidence of Edwards Syndrome in relation to other trisomies?

Options

• Most common trisomy in live births

• Second most common trisomy in live births

• More common than Down's Syndrome

• Rarest of the three main trisomies

Answer 1

Edwards Syndrome (Trisomy 18) is the second most common trisomy in live births after Down's Syndrome. Although it is more common than Patau Syndrome, it has a very high neonatal mortality rate with most affected individuals surviving less than one year. The severe clinical features and high mortality make this a significant chromosomal abnormality despite its relatively higher incidence compared to Trisomy 13.