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Question
What happens when histamine is discharged in large quantities during anaphylactic shock?
Options
Gradual appearance of spots over several days
Formation of blisters that take weeks to heal
Permanent darkening of the skin
Wheals may develop all over the skin within a minute or two
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Solution
When large quantities of histamine are discharged during anaphylactic shock, wheals may develop all over the skin within a minute or two. These are the characteristic urticarial reactions that appear rapidly as histamine causes local vasodilation and increased vascular permeability. The widespread and rapid appearance of wheals is a hallmark sign of systemic anaphylaxis and reflects the simultaneous activation of mast cells throughout the body. This rapid progression is why anaphylactic shock requires immediate emergency treatment.
