Question

In the inflammatory response, the absence of which one of the following would prevent all the others from happening?

Options

• Release of histamine

• Dilatation of arterioles

• Increased population of phagocytes in the area

• Increased permeability of blood vessels

Answer 1

Release of histamine

Explanation:

In the inflammatory response, histamine release is the initial step that triggers subsequent events, such as dilation of arterioles, increased vascular permeability, and the recruitment of phagocytes to the site of injury. Without the release of histamine, primarily from mast cells and basophils, these other processes would not occur, making it essential for the entire inflammatory response to proceed. Histamine causes local vasodilation and increases capillary permeability, which allows immune cells and plasma components to enter the affected tissue and fight infection effectively.