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Question
How is mature insulin different from pro-insulin secreted by pancreas in humans?
Distinguish Between
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Solution
| Sr. No. | Feature | Pro-insulin | Mature insulin |
| 1. | Structure | Pro-insulin consists of a single polypeptide chain with a C-peptide. | Mature insulin consists of two chains (A and B) linked by disulfide bridges. |
| 2. | C-peptide | In pro-insulin, the C-peptide is present. | It is removed during the maturation to form mature insulin. |
| 3. | Activity | Pro-insulin is inactive. | Mature insulin is fully active. |
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