Question

How does a chromosomal disorder differ from a Mendelian disorder? Write one example for each.

Answer 1

1. Chromosomal Disorder: An anomaly in the quantity or arrangement of chromosomes results in a chromosomal disease. For example, Down syndrome is brought on by an extra copy of chromosome 21.
2. Mendelian Disorder: Mutations in a single gene that follow Mendelian inheritance patterns result in a Mendelian disease. As an illustration, consider cystic fibrosis, which is an inherited autosomal disorder caused by a mutation in the CFTR gene.