Question

Why is RNA less stable than DNA?

Options

• RNA is not protected by any proteins

• The 2′-OH group in ribose makes RNA susceptible to hydrolysis under alkaline conditions

• RNA lacks the thymine base

• RNA is single-stranded in all organisms

Answer 1

RNA is less stable because the 2′-OH group present in the ribose sugar makes RNA susceptible to hydrolysis under alkaline conditions. This reactive hydroxyl group is absent in DNA's deoxyribose, providing DNA with greater chemical stability.