Question

Who among the following has developed technique to synthesize artificial mRNA with known repeated sequences of two or three nucleotides?

Options

• F.H.C. Crick

• Nirenberg and Matthaei

• Dr. Har Gobind Khorana

• Severo Ochoa

Answer 1

Dr. Har Gobind Khorana

Explanation:

Khorana developed methods to chemically synthesize long polyribonucleotides made of defined repeating di‑ and tri‑nucleotide sequences (e.g., CUC UCU … or CUA CUA …). Those synthetic RNAs were used in cell‑free translation experiments that helped assign many codons.