Question

Which type of mutation involves the substitution of a single base pair?

Options

• Insertion mutation

• Chromosomal mutation

• Frameshift mutation

• Point mutation

Answer 1

A point mutation, also called base substitution, involves the substitution of one base pair at a single nucleotide location. This type of gene mutation operates at the molecular level and does not shift the reading frame of codons, as seen in classic examples like sickle cell anaemia.