Question

Which trisomy is associated with kidney and lung defects in addition to cardiac abnormalities?

Options

• Down's Syndrome (Trisomy 21)

• Patau Syndrome (Trisomy 13)

• Tetrasomy (2n + 2)

• Edwards Syndrome (Trisomy 18)

Answer 1

Edwards Syndrome (Trisomy 18) is characterized by congenital defects involving the heart, kidneys, and lungs, in addition to other severe manifestations including intellectual disability, 'rocker-bottom' feet, and overlapping fingers with clenched fists. The multiple organ involvement and very high neonatal mortality, with most affected infants surviving less than one year, distinguish Edwards Syndrome as particularly severe among the viable autosomal trisomies.