Question

Which pharmacological agents, including \[\text{PGE}_2\] and \[\text{PGF}_{2\alpha}\], are administered to stimulate uterine contractions in late first-trimester and second-trimester terminations?

Options

• Progestins

• Gonadotropins

• Prostaglandins

• Estrogens

Answer 1

Prostaglandins (such as \[\text{PGE}_2\], \[\text{PGF}_{2\alpha}\], and misoprostol) act on the myometrium to induce labour-like uterine contractions. They are used in late 1st and 2nd trimester terminations and also serve as cervical preparation agents prior to surgical procedures.