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Question
Which of the following statements about IgE antibodies is correct?
Options
IgE is the most abundant antibody in the body
IgE is produced exclusively by memory B cells
IgE is the antibody involved in allergic reactions
IgE primarily protects against bacterial infections
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Solution
IgE is the antibody specifically involved in allergic reactions. This immunoglobulin is produced by plasma cells and binds with high affinity to Fc receptors on mast cells and basophils. This IgE-mediated sensitization is the foundation of Type I hypersensitivity reactions. When allergens cross-link IgE on these cells, rapid degranulation occurs, releasing histamine and other mediators. IgE levels are typically low in non-allergic individuals but become significantly elevated in allergic and parasitic infections.
