Question

Which of the following is the primary cause of Mendelian disorders?

Options

• Numerical or structural change in chromosomes

• Age-related deterioration of chromosomal structure

• Environmental factors such as radiation exposure

• Mutation in a single gene (point mutation, deletion)

Answer 1

Mendelian disorders are specifically caused by mutations in a single gene, which can be point mutations or deletions. These disorders follow Mendel's laws of inheritance and are detectable through DNA sequencing or biochemical tests, not through karyotyping.