Question

Which of the following is the direct result of prolonged lymphatic obstruction in filariasis?

Options

• Lymph accumulation in tissues resulting in lymphedema and progressive swelling

• Immediate muscle atrophy

• Bone demineralization

• Nerve degeneration

Answer 1

Prolonged obstruction of lymph flow by adult worms causes lymph to accumulate in tissues, resulting in lymphedema and progressive swelling. This progressive tissue enlargement eventually leads to the gross deformities characteristic of elephantiasis in advanced cases.