Question

Which of the following is also called a 'gross mutation' or 'macro mutation'?

Options

• Point mutation

• Base substitution

• Chromosomal mutation

• Frameshift mutation

Answer 1

Chromosomal mutation, which operates at the gross level affecting entire chromosome segments or numbers, is also called a gross or macro mutation. These mutations involve deletion, duplication, inversion, translocation, or gain/loss of chromosomes, and are commonly seen in cancer cells and conditions like Down's syndrome (Trisomy 21).