Question

Which of the following amino acid substitution is responsible for causing sickle cell anemia?

Options

• Valine is substituted by Glutamic acid in the α globin chain at the sixth position.

• Valine is substituted by Glutamic acid in the β globin chain at the seventh position.

• Glutamic acid is substituted by Valine in the α globin chain at the sixth position.

• Glutamic acid is substituted by Valine in the β globin chain at the sixth position.

Answer 1

Glutamic acid is substituted by Valine in the β globin chain at the sixth position.