Question

Which key historical milestone occurred first in the timeline of genetic material discovery?

Options

• Hofmeister's 1848 observation of chromosomes during mitosis

• Miescher's 1869 isolation of nuclein

• The 1920 establishment that chromosomes contain proteins and DNA

• By 1926, the advancement to molecular level investigation

Answer 1

Hofmeister's observation of chromosomes during mitosis in 1848 was the earliest key milestone in understanding genetic material. This was followed by Miescher's isolation of nuclein in 1869, and later discoveries regarding chromosome composition and molecular mechanisms of inheritance.