Question

Which cells are responsible for releasing histamine and serotonin during an allergic reaction?

Options

• Mast cells and basophils

• T cells and B cells

• Neutrophils and macrophages

• Dendritic cells and helper cells

Answer 1

Mast cells and basophils are the primary cells responsible for releasing histamine and serotonin during allergic reactions. Mast cells are found in tissues, particularly near blood vessels and mucosal surfaces, while basophils circulate in the blood. When these cells are activated by allergen-IgE crosslinking, they undergo degranulation and release these chemical mediators that cause allergic manifestations.