Question

What is the relationship between previous Down's syndrome offspring and recurrence risk?

Options

• Risk is higher with previous Down's babies

• Risk only increases after age 40

• Risk is equal to the general population regardless of history

• No increased risk in subsequent pregnancies

Answer 1

The risk of Down's syndrome is higher in mothers who have previously had a baby with Down's syndrome. This increased recurrence risk is one of the factors considered in genetic counseling and prenatal screening decisions for subsequent pregnancies.