Question

What is the mechanism of action of AZT (azidothymidine) in HIV treatment?

Options

• It directly kills HIV virions

• It prevents reverse transcription

• It integrates into viral DNA to stop replication

• It boosts the immune system to eliminate all HIV

Answer 1

AZT (azidothymidine) works by preventing reverse transcription, the process by which HIV converts its RNA genome into DNA. By inhibiting this essential step in viral replication, AZT reduces viral load. Treatment with AZT has been shown to increase helper T-cell counts, improve immune function, promote weight gain, and enhance overall well-being in patients.