Question

What is Cri-du-chat syndrome associated with?

Options

• Translocation involving chromosome 5

• Duplication on chromosome 5q

• Deletion on chromosome 5p

• Inversion on chromosome 5

Answer 1

Cri-du-chat syndrome is associated with a deletion on the short arm of chromosome 5 (5p). The condition results in loss of genes and causes severe developmental effects including intellectual disability, characteristic cry resembling a cat's meow, and facial abnormalities. It is one of the most well-characterized deletion syndromes.