Question

What happens when two charged tRNAs are brought together in the ribosome?

Options

• The mRNA codon is altered

• The tRNAs are immediately released

• The amino acids dissociate from the tRNAs

• Peptide bond formation is energetically favoured

Answer 1

When two aminoacyl-tRNAs are brought together in the ribosome, peptide bond formation between their amino acids is energetically favoured. The high-energy acyl bond of the aminoacyl-tRNA provides the energy needed for this condensation reaction, catalysed by the ribosomal peptidyl transferase center.